Standard Name	VHS3 1
Systematic Name	YOR054C
Alias	YOR29-05
Feature Type	ORF, Verified
Description	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis (2, 3, 4)
Name Description	Viable in a Hal3 Sit4 background 1

Chromosomal Location	ChrXV:429857 to 427833 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VHS3
Molecular Function
Manually curated	contributes_to phosphopantothenoylcysteine decarboxylase activity (IDA, IMP) phosphopantothenoylcysteine decarboxylase activity (ISS) protein phosphatase inhibitor activity (IDA)
Biological Process
Manually curated	cellular monovalent inorganic cation homeostasis (IGI, IPI) coenzyme A biosynthetic process (ISS)
Cellular Component
Manually curated	phosphopantothenoylcysteine decarboxylase complex (IDA)

Pathways	pantothenate and coenzyme A biosynthesis

Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to benzo[a]pyrene: decreased resistance to benzo[a]pyrene: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	92 total interaction(s) for 73 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 8 PCA: 10 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 7 Negative Genetic: 40 Phenotypic Enhancement: 1 Phenotypic Suppression: 5 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:429857 to 427833 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2025 429857..427833 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005580