Standard Name	DBP5
Systematic Name	YOR046C
Alias	RAT8 1
Feature Type	ORF, Verified
Description	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p (2, 3, 4, 5)
Name Description	Dead Box Protein

Chromosomal Location	ChrXV:415907 to 414459 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for DBP5
Molecular Function
Manually curated	contributes_to inositol hexakisphosphate binding (IDA) RNA helicase activity (IDA, ISS) RNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	mRNA export from nucleus (IGI, IMP) translational termination (IGI, IPI)
Cellular Component
Manually curated	cellular bud tip (IDA) cytoplasm (IDA) nuclear pore (IPI) nuclear pore cytoplasmic filaments (IDA) nucleus (IDA) polysome (IDA)

Classical genetics
conditional	heat sensitivity: increased
dominant negative	poly(A)+ mRNA localization: abnormal vegetative growth: decreased
reduction of function	inviable
unspecified	resistance to paromomycin: decreased resistance to hygromycin B: decreased
Large-scale survey
null	haploinsufficient inviable
overexpression	filamentous growth: increased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	237 total interaction(s) for 170 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Biochemical Activity: 2 Co-crystal Structure: 1 Reconstituted Complex: 4 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 18 Negative Genetic: 32 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 23 Synthetic Lethality: 106 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:415907 to 414459 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1449 415907..414459 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005572