DBP5/YOR046C Summary

DBP5 BASIC INFORMATION

Standard Name	DBP5
Systematic Name	YOR046C
Alias	RAT8
Feature Type	ORF, Verified
Description	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination (1, 2, 3)
Name Description	Dead Box Protein

GO Annotations	All DBP5 GO evidence and references
	View Computational GO annotations for DBP5
Molecular Function
Manually curated	contributes_to inositol hexakisphosphate binding (IDA) RNA helicase activity (IDA, ISS) RNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	mRNA export from nucleus (IGI, IMP) translational termination (IGI, IPI)
Cellular Component
Manually curated	cellular bud tip (IDA) cytoplasm (IDA) nuclear pore (IPI) nucleus (IDA) polysome (IDA)

Mutant Phenotype	All DBP5 Phenotype details and references
Classical genetics
conditional	heat sensitivity: increased
reduction of function	inviable
unspecified	resistance to paromomycin: decreased resistance to hygromycin B: decreased
Large-scale survey
null	inviable
overexpression	filamentous growth: increased

Interactions	DBP5 All interactions details and references
	208 total interaction(s) for 158 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 9 Biochemical Activity: 2 Reconstituted Complex: 4 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 15 Phenotypic Enhancement: 33 Phenotypic Suppression: 9 Synthetic Growth Defect: 6 Synthetic Lethality: 108 Synthetic Rescue: 4

Sequence Information

ChrXV:415908 to 414460 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1449	415908..414460	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005572

DBP5 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for DBP5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DBP5]

1)	Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76
2)	Tseng-Rogenski SS, et al. (2003) Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes. Nucleic Acids Res 31(17):4995-5002
3)	Gross T, et al. (2007) The DEAD-box RNA helicase Dbp5 functions in translation termination. Science 315(5812):646-9

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