WHI2/YOR043W Summary Help

Standard Name WHI2 1
Systematic Name YOR043W
Feature Type ORF, Verified
Description Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression (2, 3, 4)
Name Description WHIskey 3, 5
Chromosomal Location
ChrXV:410870 to 412330 | ORF Map | GBrowse
Gbrowse
Genetic position: 9 cM
Gene Ontology Annotations All WHI2 GO evidence and references
  View Computational GO annotations for WHI2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
301 total interaction(s) for 229 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 220
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 3
  • Positive Genetic: 12
  • Synthetic Growth Defect: 19
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 5
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 486
Molecular Weight (Da) 55,346
Isoelectric Point (pI) 5.99
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:410870 to 412330 | ORF Map | GBrowse
SGD ORF map
Genetic position: 9 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1461 410870..412330 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005569
References cited on this page View Complete Literature Guide for WHI2
1) Sudbery, P.E.  (1989) Personal Communication, Mortimer Map Edition 10
2) Radcliffe P, et al.  (1997) Deregulation of CLN1 and CLN2 in the Saccharomyces cerevisiae whi2 mutant. Yeast 13(8):707-15
3) Sudbery PE, et al.  (1980) Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Nature 288(5789):401-4
4) Kaida D, et al.  (2002) Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells 7(6):543-52
5) Saul DJ and Sudbery PE  (1985) Molecular cloning of WHI2, a gene involved in the regulation of cell proliferation in Saccharomyces cerevisiae. J Gen Microbiol 131(7):1797-806