Standard Name	WHI2 1
Systematic Name	YOR043W
Feature Type	ORF, Verified
Description	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression (2, 3, 4)
Name Description	WHIskey 3, 5

Chromosomal Location	ChrXV:410870 to 412330 | ORF Map | GBrowse
	Genetic position: 9 cM

	View Computational GO annotations for WHI2
Molecular Function
Manually curated	phosphatase activator activity (IMP, IPI)
Biological Process
Manually curated	actin filament organization (IMP) endocytosis (IMP) mitochondrion degradation (IMP) regulation of growth (IMP) response to heat (IMP) response to salt stress (IMP) response to stress (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Classical genetics
null	actin cytoskeleton morphology: abnormal apoptosis: increased reactive oxygen species accumulation: increased chronological lifespan: decreased colony size: decreased endocytosis: decreased mitochondrial genome maintenance: abnormal mitochondrial morphology: abnormal mitophagy: decreased prion formation: increased resistance to methylmercury chloride: increased viability: decreased
overexpression	resistance to methylmercury chloride: decreased
Large-scale survey
null	acid pH resistance: decreased cell size: decreased glutathione excretion: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased filamentous growth: decreased invasive growth: absent resistance to sorbate: increased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to nickel sulfate: decreased resistance to ethanol: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to wortmannin: normal resistance to BPS: decreased resistance to tunicamycin: increased resistance to benzo[a]pyrene: decreased starvation resistance: decreased stress resistance: increased telomere length: decreased toxin resistance: decreased utilization of carbon source: absent vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	297 total interaction(s) for 230 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 219 Phenotypic Enhancement: 10 Phenotypic Suppression: 3 Positive Genetic: 12 Synthetic Growth Defect: 18 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 5 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:410870 to 412330 | ORF Map | GBrowse
	Genetic position: 9 cM
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1461 410870..412330 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005569