Standard Name	EXO1
Systematic Name	YOR033C
Alias	DHS1
Feature Type	ORF, Verified
Description	5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication (1, 2, 3)
Name Description	EXOnuclease 4

Chromosomal Location	ChrXV:394524 to 392416 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EXO1
Molecular Function
Manually curated	5'-3' exonuclease activity (IDA) 5'-flap endonuclease activity (IDA)
Biological Process
Manually curated	DNA double-strand break processing (IGI, IMP) gene conversion at mating-type locus, DNA double-strand break processing (IMP) meiotic DNA double-strand break processing (IGI) mismatch repair (IMP) telomere maintenance (IGI) telomeric 3' overhang formation (IGI)
Cellular Component
Manually curated	nucleus (IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	resistance to phleomycin: decreased resistance to methyl methanesulfonate: decreased viable
Large-scale survey
null	cell size: decreased competitive fitness: increased resistance to wortmannin: normal resistance to sirolimus: increased resistance to amitrole: decreased resistance to cycloheximide: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	259 total interaction(s) for 98 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 7 Far Western: 2 Protein-peptide: 1 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 18 Negative Genetic: 63 Phenotypic Enhancement: 65 Phenotypic Suppression: 30 Positive Genetic: 2 Synthetic Growth Defect: 21 Synthetic Lethality: 16 Synthetic Rescue: 22
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:394524 to 392416 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2109 394524..392416 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005559