EXO1/YOR033C Summary

EXO1 BASIC INFORMATION

Standard Name	EXO1
Systematic Name	YOR033C
Alias	DHS1
Feature Type	ORF, Verified
Description	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains (1)
Name Description	EXOnuclease 2

GO Annotations	All EXO1 GO evidence and references
	View Computational GO annotations for EXO1
Molecular Function
Manually curated	5'-3' exonuclease activity (IDA) 5'-flap endonuclease activity (IDA)
Biological Process
Manually curated	DNA double-strand break processing (IGI, IMP) gene conversion at mating-type locus, DNA double-strand break processing (IMP) mismatch repair (IMP) telomere maintenance (IGI)
Cellular Component
Manually curated	nucleus (IPI)

Mutant Phenotype	All EXO1 Phenotype details and references
Classical genetics
null	resistance to phleomycin: decreased
Large-scale survey
null	resistance to rapamycin: increased resistance to wortmannin: normal viable

Interactions	EXO1 All interactions details and references
	120 total interaction(s) for 49 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 3 Protein-peptide: 1 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 14 Phenotypic Enhancement: 57 Phenotypic Suppression: 2 Synthetic Growth Defect: 9 Synthetic Lethality: 11 Synthetic Rescue: 11

Sequence Information

ChrXV:394524 to 392416 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2109	394524..392416	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005559

EXO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EXO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EXO1]

1)	Tran PT, et al. (2002) Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst) 1(11):895-912
2)	Fiorentini P, et al. (1997) Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro. Mol Cell Biol 17(5):2764-73

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