CIN5/YOR028C Summary

CIN5 BASIC INFORMATION

Standard Name	CIN5
Systematic Name	YOR028C
Alias	HAL6 , YAP4
Feature Type	ORF, Verified
Description	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions (1, 2, 3)
Name Description	Chromosome INstability

GO Annotations	All CIN5 GO evidence and references
	View Computational GO annotations for CIN5
Molecular Function
Manually curated	DNA binding (IDA) RNA polymerase II transcription factor activity (ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (ISS) response to drug (IGI) response to salt stress (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Regulatory Role
Binding motifs	CIN5 Transcription Factor Binding Sites and References
	TTACRTAA TTACTAA

Mutant Phenotype	All CIN5 Phenotype details and references
Classical genetics
null	resistance to sampangine: decreased vegetative growth: normal
overexpression	resistance to sampangine: increased
Large-scale survey
null	resistance to hygromycin B: decreased viable

Interactions	CIN5 All interactions details and references
	22 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Biochemical Activity: 3 Reconstituted Complex: 2 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 5 Synthetic Rescue: 1

Sequence Information

ChrXV:384420 to 383533 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..888	384420..383533	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005554

CIN5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CIN5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CIN5]

1)	Mendizabal I, et al. (1998) Yeast putative transcription factors involved in salt tolerance. FEBS Lett 425(2):323-8
2)	Furuchi T, et al. (2001) Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae. Mol Pharmacol 59(3):470-4
3)	Sollner S, et al. (2009) Quinone reductase acts as a redox switch of the 20S yeast proteasome. EMBO Rep 10(1):65-70

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