Standard Name	STI1 1
Systematic Name	YOR027W
Feature Type	ORF, Verified
Description	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop (1, 2, 3, 4, 5)
Name Description	STress Inducible 1

Chromosomal Location	ChrXV:381053 to 382822 | ORF Map | GBrowse

	View Computational GO annotations for STI1
Molecular Function
Manually curated	ATPase inhibitor activity (IDA) Hsp70 protein binding (IDA) Hsp90 protein binding (IDA) mRNA binding (IDA)
Biological Process
Manually curated	protein folding (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IPI)

Classical genetics
null	resistance to geldanamycin: decreased resistance to radicicol: decreased resistance to molybdate: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased haploproficient heat sensitivity: increased Fus-Mid-GFP distribution: abnormal resistance to arsenite(3-): decreased resistance to L-canavanine: increased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	190 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 3 Affinity Capture-Western: 25 Co-crystal Structure: 3 Co-purification: 1 PCA: 4 Reconstituted Complex: 21 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 43 Phenotypic Enhancement: 6 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 12 Synthetic Lethality: 21
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:381053 to 382822 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1770 381053..382822 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005553