Standard Name	HST3
Systematic Name	YOR025W
Feature Type	ORF, Verified
Description	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism (1, 2, 3, 4)
Name Description	Homolog of SIR Two (SIR2) 2, 5

Chromosomal Location	ChrXV:378219 to 379562 | ORF Map | GBrowse

	View Computational GO annotations for HST3
Molecular Function
Manually curated	DNA binding (ISS) contributes_to histone deacetylase activity (IMP)
Biological Process
Manually curated	chromatin silencing at telomere (IGI) histone deacetylation (IMP) short-chain fatty acid metabolic process (IMP)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
null	NTS1 ncRNA accumulation: increased chromosome/plasmid maintenance: abnormal mitotic recombination: increased oxidative stress resistance: decreased histone H4 modification: increased toxin resistance: increased
Large-scale survey
null	competitive fitness: decreased mitotic recombination: increased Rad52-YFP distribution: increased resistance to bleomycin: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to fenpropimorph: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	281 total interaction(s) for 162 unique genes/features.
Physical Interactions	Biochemical Activity: 4 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 153 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 13 Synthetic Growth Defect: 54 Synthetic Lethality: 32 Synthetic Rescue: 19
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:378219 to 379562 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1344 378219..379562 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005551