HST3/YOR025W Summary Help

HST3 BASIC INFORMATION

Standard Name HST3
Systematic Name YOR025W
Feature Type ORF, Verified
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism (1, 2, 3, 4)
Name Description Homolog of SIR Two (SIR2) 2, 5
GO Annotations All HST3 GO evidence and references
    View Computational GO annotations for HST3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All HST3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions HST3 All interactions details and references
129 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Biochemical Activity: 4
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 45
  • Phenotypic Suppression: 10
  • Synthetic Growth Defect: 42
  • Synthetic Lethality: 22
  • Synthetic Rescue: 5
Sequence Information
ChrXV:378219 to 379562 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1344 378219..379562 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005551

HST3 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HST3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HST3]

1) Smith JS, et al.  (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63
2) Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902
3) Grunweller A and Ehrenhofer-Murray AE  (2002) A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity. Genetics 162(1):59-71
4) Starai VJ, et al.  (2003) Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163(2):545-55
5) Derbyshire MK, et al.  (1996) HST1, a new member of the SIR2 family of genes. Yeast 12(7):631-40