HST3/YOR025W Summary Help

Standard Name HST3 1
Systematic Name YOR025W
Feature Type ORF, Verified
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism (1, 2, 3, 4)
Name Description Homolog of SIR Two (SIR2) 1, 5
Chromosomal Location
ChrXV:378219 to 379562 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HST3 GO evidence and references
  View Computational GO annotations for HST3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 154 genes
Regulators 129 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
290 total interaction(s) for 165 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 153
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 3
  • Positive Genetic: 13
  • Synthetic Growth Defect: 54
  • Synthetic Lethality: 32
  • Synthetic Rescue: 19

Resources
Expression Summary
histogram
Resources
Length (a.a.) 447
Molecular Weight (Da) 50,523
Isoelectric Point (pI) 9.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:378219 to 379562 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1344 378219..379562 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005551
References cited on this page View Complete Literature Guide for HST3
1) Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902
2) Smith JS, et al.  (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63
3) Grunweller A and Ehrenhofer-Murray AE  (2002) A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity. Genetics 162(1):59-71
4) Starai VJ, et al.  (2003) Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163(2):545-55
5) Derbyshire MK, et al.  (1996) HST1, a new member of the SIR2 family of genes. Yeast 12(7):631-40