SLG1/YOR008C Summary Help

SLG1 BASIC INFORMATION

Standard Name SLG1
Systematic Name YOR008C
Alias HCS77 , WSC1
Feature Type ORF, Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response (1, 2, 3)
Name Description Synthetic Lethal with Gap 4
GO Annotations All SLG1 GO evidence and references
    View Computational GO annotations for SLG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Regulatory modules predicted: cellcycle ( 233 )
Mutant Phenotype All SLG1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions SLG1 All interactions details and references
80 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-fractionation: 2
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Rescue: 37
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 18
  • Synthetic Rescue: 5
Sequence Information
ChrXV:342415 to 341279 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1137 342415..341279 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005534

SLG1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SLG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLG1]

1) Lodder AL, et al.  (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99
2) Gualtieri T, et al.  (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20
3) Nanduri J and Tartakoff AM  (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
4) de Bettignies G, et al.  (1999) RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae. Yeast 15(16):1719-31