Standard Name	GRE2 1
Systematic Name	YOL151W
Feature Type	ORF, Verified
Description	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description	Genes de Respuesta a Estres (stress responsive genes) 1

Chromosomal Location	ChrXV:43694 to 44722 | ORF Map | GBrowse

	View Computational GO annotations for GRE2
Molecular Function
Manually curated	3-methylbutanol:NAD(P) oxidoreductase activity (IMP) methylglyoxal reductase (NADPH-dependent) activity (IDA)
Biological Process
Manually curated	ergosterol metabolic process (IGI, IMP) filamentous growth (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	filamentous growth: increased invasive growth: increased Nup49p distribution: abnormal Nop1p distribution: abnormal resistance to brefeldin A: decreased resistance to ethylene glycol bis(2-aminoethyl)tetraacetic acid: decreased resistance to hygromycin B: decreased resistance to sodium chloride: decreased resistance to sodium dodecyl sulfate: decreased viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient oxidative stress resistance: decreased resistance to glycolaldehyde: decreased resistance to selenomethionine: increased resistance to benzo[a]pyrene: decreased resistance to cycloheximide: decreased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 16 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:43694 to 44722 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1029 43694..44722 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005511