DCP1/YOL149W Summary Help

DCP1 BASIC INFORMATION

Standard Name DCP1
Systematic Name YOL149W
Feature Type ORF, Verified
Description Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p (1, 2, 3, 4, 5)
Name Description mRNA DeCaPping 1
GO Annotations All DCP1 GO evidence and references
    View Computational GO annotations for DCP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DCP1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DCP1 All interactions details and references
84 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 18
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1
Sequence Information
ChrXV:44937 to 45632 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..696 44937..45632 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005509

DCP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for DCP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCP1]

1) Beelman CA, et al.  (1996) An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature 382(6592):642-6
2) LaGrandeur TE and Parker R  (1998) Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J 17(5):1487-96
3) Vilela C, et al.  (2000) The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex. EMBO J 19(16):4372-82
4) Fischer N and Weis K  (2002) The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J 21(11):2788-97
5) She M, et al.  (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70