SPT20/YOL148C Summary

SPT20 BASIC INFORMATION

Standard Name	SPT20
Systematic Name	YOL148C
Alias	ADA5
Feature Type	ORF, Verified
Description	Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex (1)
Name Description	SuPpressor of Ty

GO Annotations	All SPT20 GO evidence and references
	View Computational GO annotations for SPT20
Molecular Function
Manually curated	transcription cofactor activity (IGI, IMP, IPI)
Biological Process
Manually curated	chromatin modification (IDA) histone acetylation (IDA) UFP-specific transcription factor mRNA processing during unfolded protein response (IMP)
Cellular Component
Manually curated	SAGA complex (IDA) SLIK (SAGA-like) complex (IDA)

Mutant Phenotype	All SPT20 Phenotype details and references
Classical genetics
null	osmotic stress resistance: decreased oxidative stress resistance: decreased resistance to mycophenolic acid: decreased resistance to 6-azauracil: decreased
Large-scale survey
null	alkaline pH resistance: decreased bud morphology: abnormal glycogen accumulation: decreased freeze-thaw resistance: decreased metal resistance: decreased resistance to rapamycin: decreased resistance to wortmannin: decreased resistance to calcium dichloride: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to farnesol: decreased resistance to cadmium dichloride: decreased resistance to doxorubicin: decreased resistance to ethanol: decreased respiratory growth: absent sporulation: absent utilization of carbon source: decreased vegetative growth: absent
overexpression	silencing: abnormal

Interactions	SPT20 All interactions details and references
	158 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 76 Affinity Capture-RNA: 1 Affinity Capture-Western: 19 Biochemical Activity: 1 Co-fractionation: 1 Co-localization: 3 Co-purification: 7 Reconstituted Complex: 8 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 3 Synthetic Growth Defect: 8 Synthetic Lethality: 23 Synthetic Rescue: 7

Sequence Information

ChrXV:47573 to 45759 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1815	47573..45759	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005508

SPT20 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SPT20

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPT20]

1)	Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53

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