RIB4/YOL143C Summary Help

Standard Name RIB4 1
Systematic Name YOL143C
Feature Type ORF, Verified
Description Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase (2, 3)
Name Description RIBoflavin biosynthesis 1
Chromosomal Location
ChrXV:55104 to 54595 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RIB4 GO evidence and references
  View Computational GO annotations for RIB4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
25 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 6
  • Two-hybrid: 5

Genetic Interactions
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 169
Molecular Weight (Da) 18,555
Isoelectric Point (pI) 6.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:55104 to 54595 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..510 55104..54595 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005503
References cited on this page View Complete Literature Guide for RIB4
1) Oltmanns O and Bacher A  (1972) Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 . J Bacteriol 110(3):818-22
2) Mortl S, et al.  (1996) Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. J Biol Chem 271(52):33201-7
3) Garcia-Ramirez JJ, et al.  (1995) The Saccharomyces cerevisiae RIB4 gene codes for 6,7-dimethyl-8-ribityllumazine synthase involved in riboflavin biosynthesis. Molecular characterization of the gene and purification of the encoded protein. J Biol Chem 270(40):23801-7