HRP1/YOL123W Summary Help

Standard Name HRP1 1
Systematic Name YOL123W
Alias NAB4 , NAB5
Feature Type ORF, Verified
Description Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences (1, 2, 3, 4)
Name Description Heterogenous nuclear RibonucleoProtein 1
Chromosomal Location
ChrXV:87844 to 89448 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HRP1 GO evidence and references
  View Computational GO annotations for HRP1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
reduction of function
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
92 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 37
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 15
  • Biochemical Activity: 7
  • Co-localization: 1
  • Co-purification: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 1
  • Negative Genetic: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 534
Molecular Weight (Da) 59,650
Isoelectric Point (pI) 5.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:87844 to 89448 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1605 87844..89448 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005483
References cited on this page View Complete Literature Guide for HRP1
1) Henry M, et al.  (1996) Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3. Genetics 142(1):103-15
2) Chen S and Hyman LE  (1998) A specific RNA-protein interaction at yeast polyadenylation efficiency elements. Nucleic Acids Res 26(21):4965-74
3) Kessler MM, et al.  (1997) Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast. Genes Dev 11(19):2545-56
4) Valentini SR, et al.  (1999) Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. RNA 5(2):272-80