RRI2/YOL117W Summary

RRI2 BASIC INFORMATION

Standard Name	RRI2
Systematic Name	YOL117W
Alias	CSN10
Feature Type	ORF, Verified
Description	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response (1, 2)

GO Annotations	All RRI2 GO evidence and references
	View Computational GO annotations for RRI2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	adaptation to pheromone during conjugation with cellular fusion (IGI) cullin deneddylation (IMP)
Cellular Component
Manually curated	signalosome (IDA)

Mutant Phenotype	All RRI2 Phenotype details and references
Classical genetics
null	Cdc53p modification: increased shmoo formation: increased rate
overexpression	recovery from pheromone-induced cell cycle arrest: increased
Large-scale survey
null	resistance to nickel sulfate: increased viable

Interactions	RRI2 All interactions details and references
	27 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 5 Phenotypic Suppression: 1

Sequence Information

ChrXV:97551 to 99488 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1938	97551..99488	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005477

RRI2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RRI2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRI2]

1)	Wee S, et al. (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
2)	Maytal-Kivity V, et al. (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21

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