Standard Name	SKM1 1
Systematic Name	YOL113W
Feature Type	ORF, Verified
Description	Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	STE20/PAK homologous Kinase related to Morphogenesis 1

Chromosomal Location	ChrXV:104326 to 106293 | ORF Map | GBrowse

	View Computational GO annotations for SKM1
Molecular Function
Manually curated	protein serine/threonine kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cytokinetic cell separation (IMP) negative regulation of gene expression (IGI, IMP) protein phosphorylation (ISS) sterol import (IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	nucleus (IDA, IMP) plasma membrane (IDA)

Regulatory modules	predicted: cellcycle (365, 335, 311)

Classical genetics
null	PDR11-lacZ accumulation: increased sterol ester accumulation: increased viable
overexpression	AUS1-lacZ accumulation: decreased cellular morphology: abnormal viability: decreased
Large-scale survey
null	competitive fitness: increased hyperosmotic stress resistance: decreased resistance to hydrogen chloride: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	149 total interaction(s) for 139 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 39 PCA: 1 Protein-peptide: 2 Reconstituted Complex: 8 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 6 Dosage Rescue: 1 Negative Genetic: 68 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:104326 to 106293 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1968 104326..106293 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005473