SKM1/YOL113W Summary

SKM1 BASIC INFORMATION

Standard Name	SKM1 1
Systematic Name	YOL113W
Feature Type	ORF, Verified
Description	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth (1, 2)
Name Description	STE20/PAK homologous Kinase related to Morphogenesis 1

GO Annotations	All SKM1 GO evidence and references
	View Computational GO annotations for SKM1
Molecular Function
Manually curated	protein serine/threonine kinase activity (ISS)
Biological Process
Manually curated	cell separation during cytokinesis (IMP) protein amino acid phosphorylation (ISS) regulation of cell cycle (IGI)
Cellular Component
Manually curated	plasma membrane (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 365 , 335 , 311 )

Mutant Phenotype	All SKM1 Phenotype details and references
Classical genetics
null	viable
overexpression	cellular morphology: abnormal viability: decreased
Large-scale survey
null	hyperosmotic stress resistance: decreased viable

Interactions	SKM1 All interactions details and references
	61 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 1 Biochemical Activity: 39 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 6 Phenotypic Suppression: 3 Synthetic Growth Defect: 2 Synthetic Rescue: 1

Sequence Information

ChrXV:104326 to 106293 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1968	104326..106293	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005473

SKM1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SKM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SKM1]

1)	Martin H, et al. (1997) Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Mol Microbiol 23(3):431-44
2)	Richman TJ, et al. (1999) The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. J Biol Chem 274(24):16861-70

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.