Standard Name	SHR5
Systematic Name	YOL110W
Alias	ERF4 1
Feature Type	ORF, Verified
Description	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization (2, 3, 4)
Name Description	Suppressor of Hyperactive Ras 5

Chromosomal Location	ChrXV:109176 to 109889 | ORF Map | GBrowse

	View Computational GO annotations for SHR5
Molecular Function
Manually curated	contributes_to palmitoyltransferase activity (IDA)
Biological Process
Manually curated	protein palmitoylation (IDA, IMP) protein targeting to membrane (IMP)
Cellular Component
Manually curated	endoplasmic reticulum palmitoyltransferase complex (IPI) extrinsic to endoplasmic reticulum membrane (IDA)

Classical genetics
null	palmitoylated protein modification: decreased
Large-scale survey
null	auxotrophy competitive fitness: increased dessication resistance: decreased metal resistance: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to 1,4-dithiothreitol: decreased resistance to tunicamycin: decreased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	47 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 1 PCA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 19 Phenotypic Suppression: 4 Positive Genetic: 10 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:109176 to 109889 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..714 109176..109889 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005470