Standard Name	INO4
Systematic Name	YOL108C
Feature Type	ORF, Verified
Description	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain (1, 2)
Name Description	INOsitol requiring

Chromosomal Location	ChrXV:111886 to 111431 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for INO4
Molecular Function
Manually curated	DNA binding (IDA) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA, IMP, IPI)
Biological Process
Manually curated	phospholipid biosynthetic process (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP, IPI)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	Predicted INO4 Binding Site Locations
	CATGTGAA 3 [Search intergenic regions for CATGTGAA] CATGTGAAAT 4 [Search intergenic regions for CATGTGAAAT]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	tellurium atom accumulation: decreased GFP-Ino2 distribution: abnormal resistance to tellurite: decreased
Large-scale survey
null	glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased endocytosis: decreased haploinsufficient lipid particle morphology: abnormal resistance to benzo[a]pyrene: increased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to sirolimus: decreased resistance to chloroquine: decreased resistance to mefloquine: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to fenpropimorph: decreased resistance to glycolaldehyde: decreased respiratory growth: decreased stress resistance: increased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	473 total interaction(s) for 322 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-localization: 1 Far Western: 1 Reconstituted Complex: 2 Two-hybrid: 17
Genetic Interactions	Negative Genetic: 272 Phenotypic Enhancement: 1 Positive Genetic: 148 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:111886 to 111431 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..456 111886..111431 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005468