WSC3/YOL105C Summary Help

Standard Name WSC3 1
Systematic Name YOL105C
Feature Type ORF, Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description cell Wall integrity and Stress response Component 1
Chromosomal Location
ChrXV:115808 to 114138 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All WSC3 GO evidence and references
  View Computational GO annotations for WSC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
34 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 10
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 12
  • Negative Genetic: 6
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 556
Molecular Weight (Da) 58,229
Isoelectric Point (pI) 5.99
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:115808 to 114138 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1671 115808..114138 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005465
References cited on this page View Complete Literature Guide for WSC3
1) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
2) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
3) Sekiya-Kawasaki M, et al.  (2002) Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics 162(2):663-76
4) Wojda I, et al.  (2003) Response to high osmotic conditions and elevated temperature in Saccharomyces cerevisiae is controlled by intracellular glycerol and involves coordinate activity of MAP kinase pathways. Microbiology 149(Pt 5):1193-204
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61