Standard Name	PKH2 1
Systematic Name	YOL100W
Feature Type	ORF, Verified
Description	Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Pkb-activating Kinase Homolog 1

Chromosomal Location	ChrXV:129237 to 132482 | ORF Map | GBrowse

	View Computational GO annotations for PKH2
Molecular Function
Manually curated	protein kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cytoplasmic mRNA processing body assembly (IGI) MAPK cascade involved in cell wall biogenesis (IGI, IMP) protein phosphorylation (IDA) regulation of nuclear-transcribed mRNA poly(A) tail shortening (IGI)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cell cortex (IDA) eisosome (IDA) nucleus (IDA)

Classical genetics
null	chronological lifespan: increased heat sensitivity: decreased inviable oxidative stress resistance: increased Sch9p modification: decreased sporulation: absent vegetative growth: normal vegetative growth: decreased viable
Large-scale survey
null	acid pH resistance: decreased competitive fitness: increased competitive fitness: decreased endocytosis: decreased replicative lifespan: increased resistance to dimethyl sulfoxide: decreased resistance to benzo[a]pyrene: decreased sporulation: decreased sporulation efficiency: decreased stress resistance: increased toxin resistance: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	102 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 8 PCA: 6 Reconstituted Complex: 37 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 16 Phenotypic Enhancement: 1 Synthetic Growth Defect: 17 Synthetic Lethality: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:129237 to 132482 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3246 129237..132482 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005460