Standard Name	HMI1 1
Systematic Name	YOL095C
Feature Type	ORF, Verified
Description	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD (2, 3)
Name Description	Helicase in MItochondria 1

Chromosomal Location	ChrXV:141347 to 139227 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HMI1
Molecular Function
Manually curated	ATP-dependent 3'-5' DNA helicase activity (IDA)
Biological Process
Manually curated	mitochondrial DNA metabolic process (IMP) mitochondrial genome maintenance (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	cell shape: abnormal heat sensitivity: increased invasive growth: decreased mitochondrial genome maintenance: decreased mitochondrial genome maintenance: abnormal petite respiratory growth: decreased rate vegetative growth: decreased viable
unspecified	respiratory metabolism: normal
Large-scale survey
null	glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased competitive fitness: increased heat sensitivity: increased resistance to sorbic acid: decreased resistance to ethanol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to trichothecene: increased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased toxin resistance: increased vegetative growth: decreased rate viable
overexpression	resistance to LY-83583: increased resistance to sirolimus: decreased
unspecified	filamentous growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	126 total interaction(s) for 98 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 104 Positive Genetic: 10 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:141347 to 139227 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2121 141347..139227 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005455