YPQ1/YOL092W Summary Help

Standard Name YPQ1 1
Systematic Name YOL092W
Feature Type ORF, Verified
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication (1, 2)
Name Description Yeast PQ-loop protein 1
Chromosomal Location
ChrXV:144204 to 145130 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YPQ1 GO evidence and references
  View Computational GO annotations for YPQ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
unspecified
Resources
44 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 36
  • Positive Genetic: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 308
Molecular Weight (Da) 34,872
Isoelectric Point (pI) 4.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:144204 to 145130 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..927 144204..145130 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005452
References cited on this page View Complete Literature Guide for YPQ1
1) Jezegou A, et al.  (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc Natl Acad Sci U S A 109(50):E3434-43
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61