BRX1/YOL077C Summary

BRX1 BASIC INFORMATION

Standard Name	BRX1 1
Systematic Name	YOL077C
Feature Type	ORF, Verified
Description	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif (1, 2, 3, 4)
Name Description	Xenopus laevis Brix (Biogenesis of Ribosomes in Xenopus) homolog 1

GO Annotations	All BRX1 GO evidence and references
	View Computational GO annotations for BRX1
Molecular Function
Manually curated	5S rRNA binding (IPI) rRNA primary transcript binding (IPI)
Biological Process
Manually curated	ribosomal large subunit assembly (IPI)
Cellular Component
Manually curated	nucleolus (IPI) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Mutant Phenotype	All BRX1 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	filamentous growth: increased inviable

Interactions	BRX1 All interactions details and references
	174 total interaction(s) for 96 unique genes/features.
Physical Interactions	Affinity Capture-MS: 135 Affinity Capture-Western: 6 Biochemical Activity: 2 PCA: 10
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 6 Phenotypic Suppression: 13 Synthetic Lethality: 1

Sequence Information

ChrXV:186723 to 185848 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..876	186723..185848	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005437

BRX1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BRX1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BRX1]

1)	Kaser A, et al. (2001) Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. Biol Chem 382(12):1637-47
2)	Wehner KA and Baserga SJ (2002) The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol Cell 9(2):329-39
3)	Bogengruber E, et al. (2003) Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. FEMS Yeast Res 3(1):35-43
4)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.