Standard Name	MDM20
Systematic Name	YOL076W
Alias	DEC1 , NAA25 1
Feature Type	ORF, Verified
Description	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly (2, 3)
Name Description	Mitochondrial Distribution and Morphology

Chromosomal Location	ChrXV:187024 to 189414 | ORF Map | GBrowse

	View Computational GO annotations for MDM20
Molecular Function
Manually curated	contributes_to peptide alpha-N-acetyltransferase activity (IMP, IPI)
Biological Process
Manually curated	cytoskeleton organization (IMP) mitochondrion inheritance (IGI, IMP) N-terminal peptidyl-methionine acetylation (IGI, IMP)
Cellular Component
Manually curated	NatB complex (IDA)

Classical genetics
null	X ray resistance: increased actin cytoskeleton morphology: abnormal lithium(1+) accumulation: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased mitochondrial distribution: abnormal carboxypeptidase Y (CPY) activity: increased Nat3p accumulation: decreased Act1p modification: absent Tpm1p modification: absent iso-1-cytochrome c modification: absent resistance to dimethyl sulfoxide: decreased resistance to myriocin: decreased resistance to lithium chloride: decreased resistance to 4-nitroquinoline N-oxide: decreased resistance to ethidium bromide: decreased resistance to hydroxyurea: decreased resistance to calcium dichloride: decreased resistance to benomyl: decreased resistance to thiabendazole: decreased resistance to bleomycin: decreased resistance to ethyl methanesulfonate: decreased resistance to camptothecin: decreased resistance to caffeine: decreased respiratory growth: decreased vacuolar distribution: abnormal vegetative growth: decreased
Large-scale survey
null	UV resistance: decreased budding pattern: abnormal cell shape: abnormal cell size: increased glycogen accumulation: decreased proton accumulation: decreased competitive fitness: decreased heat sensitivity: increased ionic stress resistance: decreased lipid particle morphology: abnormal metal resistance: decreased mitochondrial morphology: abnormal Rad52-YFP distribution: increased resistance to dimethyl sulfoxide: decreased resistance to sodium selenide: decreased resistance to 2,4-dichlorophenol: decreased resistance to methyl methanesulfonate: decreased resistance to quinine: decreased resistance to sodium arsenite: decreased resistance to acetic acid: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to tirapazamine: decreased resistance to dihydromotuporamine C: decreased resistance to oleate: decreased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to sorbate: decreased resistance to hygromycin B: decreased resistance to doxorubicin: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-Western: 1 Co-fractionation: 2
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 3 Phenotypic Enhancement: 2 Synthetic Growth Defect: 19 Synthetic Lethality: 13 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:187024 to 189414 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2391 187024..189414 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005436