THP1/YOL072W Summary Help

THP1 BASIC INFORMATION

Standard Name THP1 1
Systematic Name YOL072W
Alias BUD29 2
Feature Type ORF, Verified
Description Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding (3, 4, 5)
Name Description Tho2/Hpr1 Phenotype 1
GO Annotations All THP1 GO evidence and references
    View Computational GO annotations for THP1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All THP1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions THP1 All interactions details and references
228 total interaction(s) for 147 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 23
  • Biochemical Activity: 2
  • Reconstituted Complex: 1
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 120
  • Phenotypic Suppression: 36
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 26
  • Synthetic Rescue: 1
Sequence Information
ChrXV:194970 to 196337 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1368 194970..196337 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005433

THP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for THP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for THP1]

1) Gallardo M and Aguilera A  (2001) A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination. Genetics 157(1):79-89
2) Ni L and Snyder M  (2001) A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae. Mol Biol Cell 12(7):2147-70
3) Fischer T, et al.  (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52
4) Gallardo M, et al.  (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32
5) Ciccarelli FD, et al.  (2003) The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics 4():64