Standard Name	EMI5 1
Systematic Name	YOL071W
Alias	SDH5 2
Feature Type	ORF, Verified
Description	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) (1, 2, 3, 4)
Name Description	Early Meiotic Induction 1

Chromosomal Location	ChrXV:196507 to 196995 | ORF Map | GBrowse

	View Computational GO annotations for EMI5
Molecular Function
Manually curated	contributes_to succinate dehydrogenase (ubiquinone) activity (IMP, IPI)
Biological Process
Manually curated	cellular respiration (IMP) mitochondrial electron transport, succinate to ubiquinone (IMP) protein-FAD linkage (IMP) tricarboxylic acid cycle (IPI)
High-throughput	ascospore formation (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA) mitochondrial respiratory chain complex II (IPI)
High-throughput	mitochondrion (IDA)

Classical genetics
null	acetic acid excretion: increased chronological lifespan: decreased oxidative stress resistance: decreased respiratory growth: absent respiratory metabolism: decreased sporulation efficiency: decreased
Large-scale survey
null	anaerobic growth: decreased polyphosphate accumulation: abnormal competitive fitness: increased dessication resistance: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased respiratory growth: absent respiratory growth: decreased rate sporulation: absent sporulation efficiency: decreased utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	29 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 3 Affinity Capture-Western: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Suppression: 1 Positive Genetic: 6 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:196507 to 196995 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..489 196507..196995 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005432