NUF2/YOL069W Summary Help

NUF2 BASIC INFORMATION

Standard Name NUF2
Systematic Name YOL069W
Feature Type ORF, Verified
Description Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering (1, 2, 3, 4)
Name Description NUclear Filament-containing protein 1
GO Annotations All NUF2 GO evidence and references
    View Computational GO annotations for NUF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NUF2 Phenotype details and references
Large-scale survey
conditional
null
Interactions NUF2 All interactions details and references
89 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 13
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 49
Genetic Interactions
  • Dosage Rescue: 2
  • Synthetic Lethality: 5
Sequence Information
ChrXV:198942 to 200297 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1356 198942..200297 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005430

NUF2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NUF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NUF2]

1) Osborne MA, et al.  (1994) Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. J Cell Biol 125(4):853-66
2) Wigge PA and Kilmartin JV  (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152(2):349-60
3) Janke C, et al.  (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J 20(4):777-91
4) He X, et al.  (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206