RTG1/YOL067C Summary Help

Standard Name RTG1 1
Systematic Name YOL067C
Feature Type ORF, Verified
Description Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p (1, 2, 3, 4, 5)
Name Description ReTroGrade regulation 1
Chromosomal Location
ChrXV:202518 to 201985 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All RTG1 GO evidence and references
  View Computational GO annotations for RTG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 3 genes
Regulators 4 genes
Classical genetics
Large-scale survey
323 total interaction(s) for 237 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 2
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 224
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 6
  • Positive Genetic: 71
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 177
Molecular Weight (Da) 19,016
Isoelectric Point (pI) 6.03
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:202518 to 201985 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..534 202518..201985 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005428
References cited on this page View Complete Literature Guide for RTG1
1) Liao X and Butow RA  (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72(1):61-71
2) Chelstowska A and Butow RA  (1995) RTG genes in yeast that function in communication between mitochondria and the nucleus are also required for expression of genes encoding peroxisomal proteins. J Biol Chem 270(30):18141-6
3) Rothermel BA, et al.  (1995) Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast. J Biol Chem 270(49):29476-82
4) Kos W, et al.  (1995) Expression of genes encoding peroxisomal proteins in Saccharomyces cerevisiae is regulated by different circuits of transcriptional control. Biochim Biophys Acta 1264(1):79-86
5) Ruiz-Roig C, et al.  (2012) The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell 23(21):4286-96