SPE2/YOL052C Summary Help

Standard Name SPE2 1
Systematic Name YOL052C
Feature Type ORF, Verified
Description S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically (2, 3)
Name Description SPErmidine auxotroph 1
Chromosomal Location
ChrXV:233636 to 232446 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -58 cM
Gene Ontology Annotations All SPE2 GO evidence and references
  View Computational GO annotations for SPE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
89 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 50
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 4
  • Positive Genetic: 14
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 396
Molecular Weight (Da) 46,232
Isoelectric Point (pI) 5.4
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:233636 to 232446 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -58 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1191 233636..232446 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005412
References cited on this page View Complete Literature Guide for SPE2
1) Whitney PA and Morris DR  (1978) Polyamine auxotrophs of Saccharomyces cerevisiae. J Bacteriol 134(1):214-20
2) Balasundaram D, et al.  (1991) Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(13):5872-6
3) Kashiwagi K, et al.  (1990) Spermidine biosynthesis in Saccharomyces cerevisiae. Biosynthesis and processing of a proenzyme form of S-adenosylmethionine decarboxylase. J Biol Chem 265(36):22321-8