Standard Name	GSH2 1, 2
Systematic Name	YOL049W
Feature Type	ORF, Verified
Description	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock (1, 2, 3)
Name Description	Glutathione 1, 2, 4

Chromosomal Location	ChrXV:238619 to 240094 | ORF Map | GBrowse

	View Computational GO annotations for GSH2
Molecular Function
Manually curated	glutathione synthase activity (IDA)
Biological Process
Manually curated	glutathione biosynthetic process (IMP)
Cellular Component
Manually curated	intracellular (TAS)

Pathways	glutathione biosynthesis superpathway of glutathione metabolism (truncated gamma-glutamyl cycle)

Classical genetics
null	cell size: increased glutathione accumulation: decreased resistance to 1,1'-azobis(N,N-dimethylformamide): increased resistance to methylglyoxal: decreased resistance to tellurite: increased toxin resistance: decreased
Large-scale survey
null	competitive fitness: decreased Rad52-YFP distribution: increased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to cadmium dichloride: decreased resistance to sorbate: decreased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to quinine: decreased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	47 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 1
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 26 Phenotypic Enhancement: 1 Positive Genetic: 7 Synthetic Growth Defect: 5 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:238619 to 240094 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1476 238619..240094 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005409