Standard Name	PSK2
Systematic Name	YOL045W
Feature Type	ORF, Verified
Description	PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Pas domain-containing Serine/threonine protein Kinase 2

Chromosomal Location	ChrXV:243497 to 246802 | ORF Map | GBrowse

	View Computational GO annotations for PSK2
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA, IMP)
Biological Process
Manually curated	negative regulation of glycogen biosynthetic process (IGI, IMP) protein phosphorylation (IDA, IMP) regulation of (1->6)-beta-D-glucan biosynthetic process (IGI)
Cellular Component
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
null	glycogen accumulation: increased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent resistance to caffeine: increased resistance to fenpropimorph: increased resistance to bleomycin: decreased resistance to fluconazole: decreased resistance to mycophenolic acid: decreased resistance to camptothecin: decreased resistance to doxorubicin: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	151 total interaction(s) for 128 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Biochemical Activity: 4 Reconstituted Complex: 20
Genetic Interactions	Dosage Growth Defect: 4 Dosage Rescue: 14 Negative Genetic: 85 Phenotypic Enhancement: 2 Positive Genetic: 7 Synthetic Growth Defect: 6 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:243497 to 246802 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3306 243497..246802 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005405