NTG2/YOL043C Summary Help

Standard Name NTG2 1
Systematic Name YOL043C
Alias SCR2
Feature Type ORF, Verified
Description DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description eNdonuclease Three-like Glycosylase 6
Chromosomal Location
ChrXV:249534 to 248392 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All NTG2 GO evidence and references
  View Computational GO annotations for NTG2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 10 genes
Classical genetics
Large-scale survey
74 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 14
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 8
  • Positive Genetic: 3
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 8
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 380
Molecular Weight (Da) 43,844
Isoelectric Point (pI) 8.51
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:249534 to 248392 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1143 249534..248392 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005403
References cited on this page View Complete Literature Guide for NTG2
1) You HJ, et al.  (1998) Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III. Biochemistry 37(17):6033-40
2) Alseth I, et al.  (1999) The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol 19(5):3779-87
3) Meadows KL, et al.  (2003) Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function. Nucleic Acids Res 31(19):5560-7
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Griffiths LM, et al.  (2009) Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol Cell Biol 29(3):794-807
6) Eide L, et al.  (1996) Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli. Proc Natl Acad Sci U S A 93(20):10735-40