Standard Name	NOP12 1
Systematic Name	YOL041C
Feature Type	ORF, Verified
Description	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p (1, 2, 3)
Name Description	NucleOlar Protein 1

Chromosomal Location	ChrXV:252646 to 251267 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NOP12
Molecular Function
Manually curated	RNA binding (ISS)
Biological Process
Manually curated	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP)
Cellular Component
Manually curated	nucleolus (IDA) preribosome (IDA)

Classical genetics
null	27S rRNA processing intermediate accumulation: increased 35S pre-rRNA accumulation: increased mature 25S rRNA accumulation: decreased tellurium atom accumulation: increased cold sensitivity: increased 60S ribosomal subunit accumulation: decreased replicative lifespan: increased resistance to tellurite: increased vegetative growth: decreased rate viable
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to hydroxyurea: increased resistance to fluconazole: increased resistance to caffeine: increased resistance to bleomycin: increased resistance to sodium arsenite: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to 5-fluorouracil: decreased resistance to cycloheximide: increased stress resistance: increased toxin resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	256 total interaction(s) for 201 unique genes/features.
Physical Interactions	Affinity Capture-MS: 108 Affinity Capture-RNA: 1 Biochemical Activity: 1 Two-hybrid: 3
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 82 Positive Genetic: 52 Synthetic Growth Defect: 5 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:252646 to 251267 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1380 252646..251267 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005401