PRE6/YOL038W Summary Help

PRE6 BASIC INFORMATION

Standard Name PRE6
Systematic Name YOL038W
Feature Type ORF, Verified
Description Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress (1, 2, 3)
Name Description PRoteinase yscE
GO Annotations All PRE6 GO evidence and references
    View Computational GO annotations for PRE6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PRE6 Phenotype details and references
Large-scale survey
conditional
null
repressible
Interactions PRE6 All interactions details and references
153 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 84
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 12
  • Co-fractionation: 2
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Synthetic Growth Defect: 20
  • Synthetic Rescue: 31
Sequence Information
ChrXV:255336 to 256100 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..765 255336..256100 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005398

PRE6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PRE6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRE6]

1) Heinemeyer W, et al.  (1994) PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Biochemistry 33(40):12229-37
2) Rinnerthaler M, et al.  (2006) MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim Biophys Acta 1757(5-6):631-8
3) Kusmierczyk AR, et al.  (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44