MIM1/YOL026C Summary Help

Standard Name MIM1 1
Systematic Name YOL026C
Alias TOM13 2
Feature Type ORF, Verified
Description Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Mitochondrial IMport 1
Chromosomal Location
ChrXV:274353 to 274012 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MIM1 GO evidence and references
  View Computational GO annotations for MIM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
reduction of function
repressible
Resources
20 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 9
  • Biochemical Activity: 4
  • PCA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Suppression: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 113
Molecular Weight (Da) 12,757
Isoelectric Point (pI) 4.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:274353 to 274012 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..342 274353..274012 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005386
References cited on this page View Complete Literature Guide for MIM1
1) Mnaimneh S, et al.  (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44
2) Ishikawa D, et al.  (2004) Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J Cell Biol 166(5):621-7
3) Waizenegger T, et al.  (2005) Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep 6(1):57-62
4) Hulett JM, et al.  (2008) The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex. J Mol Biol 376(3):694-704
5) Becker T, et al.  (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem 283(1):120-7
6) Papic D, et al.  (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405
7) Becker T, et al.  (2011) The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194(3):387-95
8) Dimmer KS, et al.  (2012) A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins. J Cell Sci 125(Pt 14):3464-73