TAT2/YOL020W Summary

TAT2 BASIC INFORMATION

Standard Name	TAT2 1
Systematic Name	YOL020W
Alias	LTG3 , SAB2 , SCM2 , TAP2 2
Feature Type	ORF, Verified
Description	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance (1, 2, 3, 4)
Name Description	Tryptophan Amino acid Transporter 1

GO Annotations	All TAT2 GO evidence and references
	View Computational GO annotations for TAT2
Molecular Function
Manually curated	aromatic amino acid transmembrane transporter activity (IDA) high-affinity tryptophan transmembrane transporter activity (IMP)
Biological Process
Manually curated	aromatic amino acid transport (IDA) tryptophan transport (IMP)
Cellular Component
Manually curated	plasma membrane (IDA, ISS)

Mutant Phenotype	All TAT2 Phenotype details and references
Classical genetics
null	L-tryptophan accumulation: decreased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: normal resistance to mercaptoethanol: decreased viable
overexpression	resistance to FTY720: increased resistance to FK506: increased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased telomere length: increased viable

Interactions	TAT2 All interactions details and references
	30 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Co-localization: 1 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 7 Phenotypic Suppression: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 5

Sequence Information

ChrXV:286173 to 287951 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1779	286173..287951	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000005380

TAT2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TAT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TAT2]

1)	Schmidt A, et al. (1994) Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol 14(10):6597-606
2)	Heitman J, et al. (1993) The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol 13(8):5010-9
3)	Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28
4)	Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82

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