Standard Name	TAT2 1
Systematic Name	YOL020W
Alias	LTG3 , SAB2 , SCM2 , TAP2 2
Feature Type	ORF, Verified
Description	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance (1, 2, 3, 4)
Name Description	Tryptophan Amino acid Transporter 1

Chromosomal Location	ChrXV:286172 to 287950 | ORF Map | GBrowse

	View Computational GO annotations for TAT2
Molecular Function
Manually curated	aromatic amino acid transmembrane transporter activity (IDA) high-affinity tryptophan transmembrane transporter activity (IMP)
Biological Process
Manually curated	aromatic amino acid transport (IDA) tryptophan transport (IMP)
Cellular Component
Manually curated	plasma membrane (IDA, ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	L-tryptophan accumulation: decreased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: decreased resistance to tunicamycin: normal viable
overexpression	resistance to FK506: increased resistance to FTY720: increased resistance to phytosphingosine: increased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: increased competitive fitness: decreased haploproficient resistance to L-canavanine: increased telomere length: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Co-fractionation: 1 Co-localization: 1 PCA: 5 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 2 Dosage Rescue: 9 Negative Genetic: 19 Phenotypic Suppression: 5 Positive Genetic: 9 Synthetic Growth Defect: 3 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:286172 to 287950 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1779 286172..287950 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000005380