PLB3/YOL011W Summary

PLB3 BASIC INFORMATION

Standard Name	PLB3
Systematic Name	YOL011W
Feature Type	ORF, Verified
Description	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro (1, 2)
Name Description	PhosphoLipase B 1

GO Annotations	All PLB3 GO evidence and references
	View Computational GO annotations for PLB3
Molecular Function
Manually curated	lysophospholipase activity (IMP, ISS)
Biological Process
Manually curated	phosphatidylserine catabolic process (IDA, IMP) phosphoinositide metabolic process (IDA, IMP)
Cellular Component
Manually curated	extracellular region (IDA) plasma membrane (ISS)

Mutant Phenotype	All PLB3 Phenotype details and references
Large-scale survey
null	resistance to amiodarone: decreased viable

Interactions	PLB3 All interactions details and references
	6 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 3

Sequence Information

ChrXV:305350 to 307410 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2061	305350..307410	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005371

PLB3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PLB3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PLB3]

1)	Merkel O, et al. (1999) Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. J Biol Chem 274(40):28121-7
2)	Merkel O, et al. (2005) Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Biochem J 387(Pt 2):489-96

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