Standard Name	MDM12
Systematic Name	YOL009C
Feature Type	ORF, Verified
Description	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins (1, 2, 3, 4)
Name Description	Mitochondrial Distribution and Morphology 1

Chromosomal Location	ChrXV:310139 to 309324 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MDM12
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrion inheritance (TAS) mitochondrion organization (TAS) phospholipid transport (IGI) protein import into mitochondrial outer membrane (IMP)
Cellular Component
Manually curated	ERMES complex (IPI) mitochondrial outer membrane (TAS)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA) plasma membrane (IDA)

Classical genetics
null	tellurium atom accumulation: decreased cardiolipin accumulation: decreased chromosome/plasmid maintenance: abnormal mitochondrial morphology: abnormal resistance to fenpropimorph: decreased resistance to benomyl: decreased resistance to tellurite: increased respiratory growth: absent
Large-scale survey
null	UV resistance: decreased cell size: decreased glycogen accumulation: decreased glutathione excretion: increased chitin deposition: increased competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased metal resistance: decreased mitochondrial morphology: abnormal resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased resistance to Calcofluor White: normal resistance to trichothecene: increased respiratory growth: absent respiratory growth: decreased rate starvation resistance: decreased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	222 total interaction(s) for 188 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 15 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 146 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 25 Synthetic Lethality: 12 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:310139 to 309324 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..816 310139..309324 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005369