BIO3/YNR058W Summary Help

Standard Name BIO3 1
Systematic Name YNR058W
Feature Type ORF, Verified
Description 7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria (1, 2)
Name Description BIOtin 1
Chromosomal Location
ChrXIV:734291 to 735733 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BIO3 GO evidence and references
  View Computational GO annotations for BIO3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
9 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 1
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 480
Molecular Weight (Da) 53,708
Isoelectric Point (pI) 6.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:734291 to 735733 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1443 734291..735733 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005341
References cited on this page View Complete Literature Guide for BIO3
1) Phalip V, et al.  (1999) Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Gene 232(1):43-51
2) Hall C and Dietrich FS  (2007) The Reacquisition of Biotin Prototrophy in Saccharomyces cerevisiae Involved Horizontal Gene Transfer, Gene Duplication and Gene Clustering. Genetics 177(4):2293-307