POP2/YNR052C Summary Help

Standard Name POP2 1
Systematic Name YNR052C
Alias CAF1
Feature Type ORF, Verified
Description RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation (2, 3, 4)
Name Description PGK promoter directed OverProduction 1
Chromosomal Location
ChrXIV:720647 to 719346 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All POP2 GO evidence and references
  View Computational GO annotations for POP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 755 genes
Regulators 103 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
407 total interaction(s) for 246 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 50
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 42
  • Biochemical Activity: 2
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 4
  • PCA: 9
  • Reconstituted Complex: 4
  • Two-hybrid: 24

Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 10
  • Negative Genetic: 17
  • Phenotypic Enhancement: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 134
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 92
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 433
Molecular Weight (Da) 49,682
Isoelectric Point (pI) 6.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:720647 to 719346 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1302 720647..719346 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005335
References cited on this page View Complete Literature Guide for POP2
1) Sakai A, et al.  (1992) Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae. Nucleic Acids Res 20(23):6227-33
2) Tucker M, et al.  (2002) Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO J 21(6):1427-36
3) Daugeron MC, et al.  (2001) The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res 29(12):2448-55
4) Thore S, et al.  (2003) X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. EMBO Rep 4(12):1150-5