POP2/YNR052C Summary Help

POP2 BASIC INFORMATION

Standard Name POP2
Systematic Name YNR052C
Alias CAF1
Feature Type ORF, Verified
Description RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation (1, 2, 3)
Name Description PGK promoter directed OverProduction 4
GO Annotations All POP2 GO evidence and references
    View Computational GO annotations for POP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All POP2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions POP2 All interactions details and references
318 total interaction(s) for 188 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 42
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 33
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Co-purification: 4
  • PCA: 9
  • Reconstituted Complex: 2
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 9
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 93
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 88
  • Synthetic Rescue: 7
Sequence Information
ChrXIV:720650 to 719349 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1302 720650..719349 2010-01-05 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005335

POP2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for POP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for POP2]

1) Tucker M, et al.  (2002) Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO J 21(6):1427-36
2) Daugeron MC, et al.  (2001) The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res 29(12):2448-55
3) Thore S, et al.  (2003) X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. EMBO Rep 4(12):1150-5
4) Sakai A, et al.  (1992) Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae. Nucleic Acids Res 20(23):6227-33