BRE5/YNR051C Summary

BRE5 BASIC INFORMATION

Standard Name	BRE5
Systematic Name	YNR051C
Feature Type	ORF, Verified
Description	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A (1, 2)
Name Description	BREfeldin A sensitivity 1

GO Annotations	All BRE5 GO evidence and references
	View Computational GO annotations for BRE5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	protein deubiquitination (IMP) ribophagy (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All BRE5 Phenotype details and references
Classical genetics
null	meiosis: abnormal protein transport: abnormal replicative lifespan: increased resistance to brefeldin A: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	acid pH resistance: decreased chitin deposition: increased competitive fitness: decreased filamentous growth: decreased invasive growth: absent replicative lifespan: increased resistance to Calcofluor White: decreased resistance to caffeine: decreased resistance to monensin: decreased resistance to PM02734: decreased resistance to ethanol: decreased sporulation: abnormal viable
overexpression	resistance to rapamycin: increased

Interactions	BRE5 All interactions details and references
	350 total interaction(s) for 241 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-Western: 4 Co-crystal Structure: 2 Co-purification: 1 PCA: 5 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 179 Phenotypic Suppression: 64 Synthetic Growth Defect: 28 Synthetic Lethality: 39

Sequence Information

ChrXIV:718330 to 716783 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2010-01-05 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1548	718330..716783	2010-01-05	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005334

BRE5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BRE5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BRE5]

1)	Muren E, et al. (2001) Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast 18(2):163-72
2)	Cohen M, et al. (2003) Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. J Biol Chem 278(52):51989-92

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