BRE5/YNR051C Summary Help

Standard Name BRE5 1
Systematic Name YNR051C
Feature Type ORF, Verified
Description Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A (1, 2)
Name Description BREfeldin A sensitivity 1
Chromosomal Location
ChrXIV:718327 to 716780 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All BRE5 GO evidence and references
  View Computational GO annotations for BRE5
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
1415 total interaction(s) for 895 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 398
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 7
  • Co-crystal Structure: 2
  • Co-purification: 1
  • PCA: 5
  • Reconstituted Complex: 3
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 690
  • Phenotypic Enhancement: 27
  • Phenotypic Suppression: 38
  • Positive Genetic: 157
  • Synthetic Growth Defect: 51
  • Synthetic Lethality: 25
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 515
Molecular Weight (Da) 57,674
Isoelectric Point (pI) 9.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:718327 to 716780 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1548 718327..716780 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005334
References cited on this page View Complete Literature Guide for BRE5
1) Muren E, et al.  (2001) Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast 18(2):163-72
2) Cohen M, et al.  (2003) Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. J Biol Chem 278(52):51989-92