ARC35/YNR035C Summary

ARC35 BASIC INFORMATION

Standard Name	ARC35 1
Systematic Name	YNR035C
Alias	END9 2
Feature Type	ORF, Verified
Description	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin (1, 2)
Name Description	ARp2/3 Complex subunit 1

GO Annotations	All ARC35 GO evidence and references
	View Computational GO annotations for ARC35
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	actin cytoskeleton organization (IGI, IMP, IPI) microtubule cytoskeleton organization (IGI, IMP, IPI) mitochondrion inheritance (TAS) receptor-mediated endocytosis (IMP)
Cellular Component
Manually curated	Arp2/3 protein complex (IDA) cytosol (IPI)

Mutant Phenotype	All ARC35 Phenotype details and references
Classical genetics
conditional	hyperosmotic stress resistance: decreased
null	actin cytoskeleton morphology: abnormal growth in exponential phase: decreased rate spore germination: decreased
Large-scale survey
null	inviable
repressible	mitochondrial morphology: abnormal

Interactions	ARC35 All interactions details and references
	80 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 2 Affinity Capture-Western: 13 Co-purification: 2 PCA: 10 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 8 Synthetic Lethality: 3 Synthetic Rescue: 1

Sequence Information

ChrXIV:694050 to 693022 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2010-01-05 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1029	694050..693022	2010-01-05	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005318

ARC35 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARC35

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARC35]

1)	Winter D, et al. (1997) The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol 7(7):519-29
2)	Schaerer-Brodbeck C and Riezman H (2000) Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Mol Biol Cell 11(4):1113-27

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