ATO2/YNR002C Summary Help

Standard Name ATO2 1
Systematic Name YNR002C
Alias FUN34 2
Feature Type ORF, Verified
Description Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication (1, 3, 4, 5, 6, 7)
Name Description Ammonia (Ammonium) Transport Outward 1
Chromosomal Location
ChrXIV:633856 to 633008 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ATO2 GO evidence and references
  View Computational GO annotations for ATO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
unspecified
Large-scale survey
null
Resources
13 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • FRET: 1
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 282
Molecular Weight (Da) 30,701
Isoelectric Point (pI) 5.09
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:633856 to 633008 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..849 633856..633008 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005285
References cited on this page View Complete Literature Guide for ATO2
1) Palkova Z, et al.  (2002) Ammonia pulses and metabolic oscillations guide yeast colony development. Mol Biol Cell 13(11):3901-14
2) Lalo D, et al.  (1993) Two yeast chromosomes are related by a fossil duplication of their centromeric regions. C R Acad Sci III 316(4):367-73
3) Augstein A, et al.  (2003) Characterization, localization and functional analysis of Gpr1p, a protein affecting sensitivity to acetic acid in the yeast Yarrowia lipolytica. Microbiology 149(Pt 3):589-600
4) Vachova L, et al.  (2004) Sok2p transcription factor is involved in adaptive program relevant for long term survival of Saccharomyces cerevisiae colonies. J Biol Chem 279(36):37973-81
5) Vachova L and Palkova Z  (2005) Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia. J Cell Biol 169(5):711-7
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906