EMW1/YNL313C Summary Help

Standard Name EMW1 1
Systematic Name YNL313C
Feature Type ORF, Verified
Description Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description Essential for Maintenance of the cell Wall 1
Chromosomal Location
ChrXIV:48022 to 45308 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EMW1 GO evidence and references
  View Computational GO annotations for EMW1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
45 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 4
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 9
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 904
Molecular Weight (Da) 102,335
Isoelectric Point (pI) 5.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:48022 to 45308 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2715 48022..45308 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005257
References cited on this page View Complete Literature Guide for EMW1
1) Sipling T, et al.  (2011) Emw1p/YNL313cp is essential for maintenance of the cell wall in Saccharomyces cerevisiae. Microbiology 157(Pt 4):1032-41
2) Maftahi M, et al.  (1998) Generation of Saccharomyces cerevisiae deletants and basic phenotypic analysis of eight novel genes from the left arm of chromosome XIV. Yeast 14(3):271-80
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76