CLA4/YNL298W Summary Help

CLA4 BASIC INFORMATION

Standard Name CLA4 1
Systematic Name YNL298W
Alias ERC10 1 , 2 , 3
Feature Type ORF, Verified
Description Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p (1, 3, 4, 5, 6)
Name Description CLn Activity dependant 7
GO Annotations All CLA4 GO evidence and references
    View Computational GO annotations for CLA4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CLA4 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions CLA4 All interactions details and references
457 total interaction(s) for 294 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 26
  • Protein-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 18
Genetic Interactions
  • Dosage Lethality: 5
  • Dosage Rescue: 9
  • Phenotypic Enhancement: 130
  • Phenotypic Suppression: 29
  • Synthetic Growth Defect: 64
  • Synthetic Lethality: 152
  • Synthetic Rescue: 3
Sequence Information
ChrXIV:68915 to 71443 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2529 68915..71443 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005242

CLA4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CLA4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CLA4]

1) Cvrckova F, et al.  (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30
2) Benton BK, et al.  (1993) Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. EMBO J 12(13):5267-75
3) Benton BK, et al.  (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76
4) Caviston JP, et al.  (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66
5) Versele M and Thorner J  (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15
6) Bartholomew CR and Hardy CF  (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72
7) Cvrckova F and Nasmyth K  (1993) Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation. EMBO J 12(13):5277-86