Standard Name	RIM21 1
Systematic Name	YNL294C
Alias	PAL2 2
Feature Type	ORF, Verified
Description	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH (1, 2, 3, 4)
Name Description	Regulator of IME2 5

Chromosomal Location	ChrXIV:80260 to 78659 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RIM21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ascospore formation (IMP) cellular response to alkalinity (IMP) fungal-type cell wall biogenesis (IGI, IMP) invasive growth in response to glucose limitation (IMP)
Cellular Component
Manually curated	plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	alkaline pH resistance: decreased ionic stress resistance: decreased Rim9p accumulation: increased Rim9p distribution: abnormal Dfg16p distribution: abnormal Hsp150p distribution: abnormal resistance to Calcofluor White: increased resistance to caffeine: decreased resistance to sodium dodecyl sulfate: decreased resistance to benomyl: decreased resistance to enzymatic treatment: decreased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased Fus-Mid-GFP distribution: abnormal resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to nickel sulfate: increased resistance to fenpropimorph: increased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to fluconazole: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to BPS: decreased resistance to glycolaldehyde: decreased stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	97 total interaction(s) for 83 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 41 Phenotypic Enhancement: 2 Positive Genetic: 4 Synthetic Growth Defect: 30 Synthetic Lethality: 12 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:80260 to 78659 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1602 80260..78659 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005238