Standard Name	MID1 1
Systematic Name	YNL291C
Feature Type	ORF, Verified
Description	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer (1, 2, 3, 4)
Name Description	Mating pheromone-Induced Death 1

Chromosomal Location	ChrXIV:85815 to 84169 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MID1
Molecular Function
Manually curated	contributes_to calcium channel activity (IMP) calcium channel activity (IMP) contributes_to stretch-activated, cation-selective, calcium channel activity (IDA)
Biological Process
Manually curated	calcium ion transport (IDA)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) plasma membrane (IDA)

Classical genetics
null	calcium(2+) accumulation: decreased calcium(2+) accumulation: absent cold sensitivity: increased ionic stress resistance: decreased recovery from pheromone-induced cell cycle arrest: absent recovery from pheromone-induced cell cycle arrest: decreased resistance to lithium chloride: decreased resistance to iron(2+): decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Plakortide F Acid: decreased viable
reduction of function	calcium(2+) accumulation: decreased
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to hydroxyurea: increased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to streptomycin: decreased resistance to sorbate: increased resistance to sirolimus: decreased resistance to (S)-lactic acid: decreased resistance to hydrogen chloride: decreased resistance to fluconazole: decreased resistance to bleomycin: decreased resistance to 1,4-dithiothreitol: decreased sporulation efficiency: increased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	93 total interaction(s) for 79 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 1 Co-fractionation: 3 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 49 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 25 Synthetic Lethality: 6 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:85815 to 84169 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1647 85815..84169 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000005235