RFC3/YNL290W Summary

RFC3 BASIC INFORMATION

Standard Name	RFC3
Systematic Name	YNL290W
Feature Type	ORF, Verified
Description	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon (1, 2)
Name Description	Replication Factor C 1

GO Annotations	All RFC3 GO evidence and references
	View Computational GO annotations for RFC3
Molecular Function
Manually curated	ATPase activity (IDA) contributes_to DNA clamp loader activity (IDA)
Biological Process
Manually curated	leading strand elongation (IDA) mismatch repair (TAS) sister chromatid cohesion (IPI)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI) DNA replication factor C complex (IDA) Elg1 RFC-like complex (IPI) Rad17 RFC-like complex (IDA)
High-throughput	nucleus (IDA)

Mutant Phenotype	All RFC3 Phenotype details and references
Large-scale survey
null	inviable

Interactions	RFC3 All interactions details and references
	80 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 34 Affinity Capture-Western: 14 Co-fractionation: 1 Co-purification: 6 PCA: 1 Reconstituted Complex: 6 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 14 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrXIV:86218 to 87240 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1023	86218..87240	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005234

RFC3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RFC3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RFC3]

1)	Cullmann G, et al. (1995) Characterization of the five replication factor C genes of Saccharomyces cerevisiae. Mol Cell Biol 15(9):4661-71
2)	Yao N, et al. (2003) Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen. J Biol Chem 278(50):50744-53

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