CAF40/YNL288W Summary

CAF40 BASIC INFORMATION

Standard Name	CAF40 1
Systematic Name	YNL288W
Feature Type	ORF, Verified
Description	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p (1)
Name Description	CCR4 Associated Factor 1

GO Annotations	All CAF40 GO evidence and references
	View Computational GO annotations for CAF40
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IPI)
Cellular Component
Manually curated	CCR4-NOT core complex (IPI)

Mutant Phenotype	All CAF40 Phenotype details and references
Classical genetics
null	resistance to caffeine: decreased
Large-scale survey
null	competitive fitness: decreased resistance to rapamycin: decreased resistance to wortmannin: normal resistance to ethanol: decreased resistance to nickel sulfate: increased sporulation: absent viable

Interactions	CAF40 All interactions details and references
	164 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 46 Affinity Capture-RNA: 2 Affinity Capture-Western: 15 Biochemical Activity: 1 Co-fractionation: 1 Co-purification: 1 PCA: 19 Two-hybrid: 14
Genetic Interactions	Phenotypic Enhancement: 45 Phenotypic Suppression: 6 Synthetic Growth Defect: 6 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 7

Sequence Information

ChrXIV:90303 to 91424 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1122	90303..91424	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005232

CAF40 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CAF40

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAF40]

1)	Chen J, et al. (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol 314(4):683-94

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