CAF40/YNL288W Summary Help

Standard Name CAF40 1
Systematic Name YNL288W
Feature Type ORF, Verified
Description Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p (1)
Name Description CCR4 Associated Factor 1
Chromosomal Location
ChrXIV:90303 to 91424 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CAF40 GO evidence and references
  View Computational GO annotations for CAF40
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
192 total interaction(s) for 108 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 25
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 23
  • Two-hybrid: 14

Genetic Interactions
  • Negative Genetic: 45
  • Phenotypic Enhancement: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 10
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 373
Molecular Weight (Da) 41,155
Isoelectric Point (pI) 7.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:90303 to 91424 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1122 90303..91424 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005232
References cited on this page View Complete Literature Guide for CAF40
1) Chen J, et al.  (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol 314(4):683-94