Standard Name	CAF40 1
Systematic Name	YNL288W
Feature Type	ORF, Verified
Description	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p (1)
Name Description	CCR4 Associated Factor 1

Chromosomal Location	ChrXIV:90303 to 91424 | ORF Map | GBrowse

	View Computational GO annotations for CAF40
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	positive regulation of transcription elongation from RNA polymerase II promoter (IDA, IPI) regulation of transcription from RNA polymerase II promoter (IPI)
Cellular Component
Manually curated	CCR4-NOT core complex (IPI)

Classical genetics
null	resistance to caffeine: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to caffeine: decreased resistance to sorbate: increased resistance to cycloheximide: decreased resistance to nickel sulfate: increased resistance to wortmannin: normal resistance to hydroxyurea: decreased resistance to fluconazole: decreased resistance to camptothecin: decreased resistance to ethanol: decreased resistance to sirolimus: decreased resistance to tunicamycin: increased resistance to fenpropimorph: increased resistance to tirapazamine: increased sporulation: absent sporulation efficiency: decreased stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	189 total interaction(s) for 106 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-RNA: 2 Affinity Capture-Western: 25 Biochemical Activity: 1 Co-fractionation: 1 Co-purification: 1 PCA: 23 Two-hybrid: 14
Genetic Interactions	Negative Genetic: 45 Phenotypic Enhancement: 1 Positive Genetic: 6 Synthetic Growth Defect: 9 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 6 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:90303 to 91424 | ORF Map | GBrowse
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1122 90303..91424 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005232