SEC21/YNL287W Summary Help

Standard Name SEC21 1
Systematic Name YNL287W
Feature Type ORF, Verified
Description Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo (2, 3)
Name Description SECretory
Chromosomal Location
ChrXIV:91994 to 94801 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEC21 GO evidence and references
  View Computational GO annotations for SEC21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
conditional
repressible
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
165 total interaction(s) for 95 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 58
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 14
  • Biochemical Activity: 1
  • Co-crystal Structure: 2
  • Co-fractionation: 4
  • PCA: 6
  • Protein-peptide: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 9
  • Negative Genetic: 32
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 17
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 935
Molecular Weight (Da) 104,830
Isoelectric Point (pI) 4.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:91994 to 94801 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2808 91994..94801 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005231
References cited on this page View Complete Literature Guide for SEC21
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Gaynor EC and Emr SD  (1997) COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol 136(4):789-802
3) Spang A, et al.  (2001) The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol Biol Cell 12(4):1035-45