WSC2/YNL283C Summary Help

WSC2 BASIC INFORMATION

Standard Name WSC2
Systematic Name YNL283C
Alias STA3
Feature Type ORF, Verified
Description Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response (1, 2, 3, 4, 5, 6, 7)
Name Description cell Wall integrity and Stress response Component 2
GO Annotations All WSC2 GO evidence and references
    View Computational GO annotations for WSC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Regulatory modules predicted: cellcycle ( 347 , 329 )
Mutant Phenotype All WSC2 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions WSC2 All interactions details and references
38 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 17
Genetic Interactions
  • Dosage Rescue: 16
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 2
Sequence Information
ChrXIV:106695 to 105184 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1512 106695..105184 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005227

WSC2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for WSC2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for WSC2]

1) Raboy B, et al.  (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39
2) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
3) Kosodo Y, et al.  (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14
4) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
5) Nanduri J and Tartakoff AM  (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
6) Ng DT  (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20
7) Imazu H and Sakurai H  (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6